Blar i forfatter "Joshi, Bishnu"

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    • Bacterial Extracellular vesicles and their cargo 

      Joshi, Bishnu (Doctoral thesis; Doktorgradsavhandling, 2021-02-05)
      <i>Staphylococcus aureus</i> and <i>Enterococcus faecium</i> are opportunistic pathogens that may cause diseases ranging from minor skin infection to severe blood stream infections. The emergence of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and vancomycin-resistant enterococcal strains severely limits treatment options. Bacteria release extracellular vesicles (EVs), defined as ...

    • Bacterial membrane-derived vesicles attenuate vancomycin activity against methicillin-resistant staphylococcus aureus 

      Kumaraswamy, Monika; Wiull, Kamilla; Joshi, Bishnu; Sakoulas, George; Kousha, Armin; Vaaje-Kolstad, Gustav; Johannessen, Mona; Hegstad, Kristin; Nizet, Victor; Askarian, Fatemeh (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-29)
      Methicillin-resistant Staphylococcus aureus (MRSA) has evolved numerous antimicrobial resistance mechanisms and is identified as a serious public health threat by the World Health Organization and U.S. Centers for Disease Control and Prevention. The glycopeptide vancomycin (VAN) remains a cornerstone of therapy for severe MRSA infections despite increasing reports of therapeutic failure in hospitalized ...

    • Enterococcus faecium produces membrane vesicles containing virulence factors and antimicrobial resistance related proteins 

      Wagner, Theresa; Joshi, Bishnu; James Peter, Jessin Janice; Askarian, Fatemeh; Skalko-Basnet, Natasa; Hagestad, Ole Christian; Mekhlif, Ahmed; Wai, Sun Nyunt; Hegstad, Kristin; Johannessen, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-30)
      <i>Enterococcus faecium</i> is a commensal but also a bacteremia causing pathogen, which is inherently resistant to several antimicrobials and has a great ability to acquire new traits. Bacterial membrane vesicles (MVs) are increasingly recognized as a mode of cell-free communication and a way to deliver virulence factors and/or antimicrobial resistance determinants. These features make MVs interesting ...

    • Transcriptome profiling of staphylococcus aureus associated extracellular vesicles reveals presence of small RNA-cargo 

      Joshi, Bishnu; Singh, Bhupender; Nadeem, Aftab; Askarian, Fatemeh; Wai, Sun Nyunt; Johannessen, Mona; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-13)
      Bacterial extracellular vesicles (EVs) have a vital role in bacterial pathogenesis. However, to date, the small RNA-cargo of EVs released by the opportunistic pathogen Staphylococcus aureus has not been characterized. Here, we shed light on the association of small RNAs with EVs secreted by S. aureus MSSA476 cultured in iron-depleted bacteriologic media supplemented with a subinhibitory dosage of ...